Figure 1
From: Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia
Rest/activity rhythm phase shift measurements in mice. LD started more than 10 days before the initiation of DD. The light phase was from ZT0 to 12 in LD. Anesthesia was performed on DD day 5 (left), and mice were divided into 6 subgroups according to the time-of-day of anesthesia (right; n = 6 per subgroup). In the group without anesthesia, the same procedure was performed when anesthesia was started. The time at the beginning of the active phase in mice (thick line) was determined from the actogram, and the time on DD day 6 was estimated. The difference from the estimated and actual beginning time of the active phase on DD day 6 was defined as the phase shift after anesthesia.
