Figure 1
From: Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells
MUC1 is significantly overexpressed in gliomas. (A) Identification of differentially expressed genes from the RNA-seq data of paired normal brain and glioma tissue of 30 glioma patients. Volcano plot showing MUC1 as one of the significant upregulated gene. (B) Comparison of MUC1 mRNA expression in normal brain tissue and glioma (WHO grade II, III, and IV) tissues. MUC1 is significantly overexpressed in all glioma samples compared to normal brain samples. (C) Comparison of MUC1 RNA expression in glioblastoma (GBM) and lower grade glioma (LGG) data from TCGA (The Cancer Genome Atlas) with normal brain data from GTEx (Genotype-Tissue Expression). MUC1 is highly expressed in both GBM and LGG. (D) Overall survivals in GBM patients in TCGA dataset classified by MUC1 expression. The prognosis is significantly poor in MUC1 overexpressed patients.
