Figure 4

Effects of i.v. NFEPP (10–1000 mg/kg) on heat hyperalgesia in mice inoculated with NCTC 2472 or RM1 cells. Effects in mice inoculated with killed NCTC 2472 cells (n = 8 in 100 nmol/kg group, n = 7 in 300 nmol/kg group, n = 5 per group for other treatments) (A) or RM1 cells (n = 5 per group) (C), or in tumor-bearing mice inoculated with live NCTC 2472 cells (n = 6 in 30 nmol/kg group, n = 5 per group for other treatments) (B) or RM1 cells (n = 6 in 100 nmol/kg group, n = 7 per group for other treatments) (D). ⁺P < 0.05, ⁺⁺P < 0.01, compared to solvent (0 nmol/kg)-treated mice (A,C); *P < 0.05, **P < 0.01, compared to the solvent-treated mice in the right paw, one-way ANOVA and Dunnett’s t test (B,D). All data are means ± SEM. For clarity, in the graphs a maximal number of two symbols of significancy are represented (the exact values are stated in the results section).