Figure 3
Representative histological images of tissues harvested from the bone-implant interface. The bone defect sites of the control (A,A’), FGF2 (B,B’), VEGF (C,C’), FGF/VEGF (D,D’), BMP4 (E,E’) and FGF/VEGF/ BMP4 (F,F’) groups at 6 weeks post-surgery are shown at two different magnification. Decalcified longitudinal sections (Movat’s pentachrome staining) are oriented with the bone defect on the bottom in all micrographs. The red dotted line points out the edge between the defect and the compact bone (A–F). The black lines indicate the defect margins (A’–F’). Scale bar: 500 μm (A–F) and 50 μm (A’–F'). Cg cartilage, cc chondrocyte, ccl chondroclast, Oc osteocyte, Ob osteoblast, Ocl osteoclast, H Haversian canal, O osteoids, bv blood vessel, rl resorption lacuna.
