Figure 7

FGFR3 GOF mice have aberrant trajectories of anterior and posterior commissures. (A,B) Representative images show the anatomical features of coronal brain sections from rostral to caudal area in control (Ctrl) and GOF mice. The olfactory bulb related structures are marked with blue rectangles. The blue arrows indicate the anterior part of the anterior commissure. The red arrows indicate the internal capsule. The blue arrowheads indicate the corpus callosum. Blue stars mark the ectopic cell clusters in GOF mouse brains. The red rectangles mark hippocampal regions. (C) Scheme illustrating the axonal projections in 3-D. C1 shows the dorsal view. C2 shows the front view from the rostral side, which is like the images in D-F. C3 represents the viewing orientation as the images in D1-F1. (D–F) The fluorescence images from Ctrl and GOF coronal brain slices. D1, E1, and F1 show the enlarged views for the area indicated with orange rectangles in (D–F). The arch-shaped olfactory limb of the anterior commissure is highlighted with purple dashed lines. The temporal limb of the anterior commissure (labeled by dashed yellow lines) is located in front of the columns of postcommissural fornix (marked by dashed blue lines). D dorsal, V ventral, A anterior, P posterior.