Figure 3
Antimicrobial resistance determinants identified in the genomes of mcr-1-positive commensal E. coli. (a) Heatmap shows the presence or absence of antimicrobial resistance determinants of commensal E. coli. The rows represent isolates and the columns correspond predicted antimicrobial resistance genes (ARGs). ARGs are predicted from whole genome sequence data using Resfinder 3.2 tool on CGE webserver. (b) Heatmap represents chromosomal known point mutation in the commensal E. coli genome. Colours indicate amino acid substitution at the corresponding mutation site. Rows and columns represent isolates and mutated genes, respectively. (c) Point mutations in pmrA and pmrB genes of commensal E. coli. Columns and rows represent amino acid substitution position and individual isolates, respectively. Dark and light blocks show the presence and absence of mutation, respectively. (d) Distribution of minimum inhibitory concentration (MIC) against colistin sulphate among E. coli strains. Rows and columns represent strains and MIC, respectively.
