Table 1 Summary of the fitting parameters for the steady-state concentration–response curves measured in HEK293 cells expressing the indicated NMDAR subunits (see Fig. 2b,d,f,h).

From: The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors

 

hGluN1-4a/hGluN2A

hGluN1-4a-S688Y/hGluN2A

hGluN1-4a/hGluN2B

hGluN1-4a-S688Y/hGluN2B

Glycine

EC50 (ÎĽM)a

1.09 ± 0.14

2122.78 ± 157.36*

0.41 ± 0.02

1100.09 ± 69.25*

h a

1.37 ± 0.05

1.67 ± 0.07

1.18 ± 0.05

1.34 ± 0.07

n

7

9

8

6

D-Serine

EC50 (ÎĽM)a

1.77 ± 0.19

1066.55 ± 29.65*

0.47 ± 0.02

152.09 ± 9.67*

ha

1.37 ± 0.03

1.48 ± 0.02

1.20 ± 0.03

1.19 ± 0.03

n

6

6

5

8

  1. aThe EC50 (in ÎĽM) and Hill coefficient (h) were obtained as described in the "Methods".
  2. *p < 0.05 vs. the corresponding hGluN1-4a group (Student’s t-test).
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