Figure 5
From: IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice
Treatment with IL-18BP increased BM clonogenicity 4 and 7 days after TBI. Mice received rhIL-18BP (2 mg/kg) or vehicle-injection at 48 h after 9.4 Gy TBI. Clonogenicity of mouse BM cells from 4 (a) and 7 (b) days after TBI was quantified in standard semisolid cultures in triplicates. CFU-GM, BFU-E and CFU-GEMM were counted 10 days later. Results were from two independent experiments (6 mice/group/experiment, N = 12). Means ± SD. Level of increase *p < 0.05; **p < 0.01; rhIL-18BP-treated vs. vehicle-treated.
