Figure 6
From: IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice
Immunohistochemical (IHC) staining of bone marrow with anti-IL-18 and IFN-γ antibodies. Mice were irradiated with 9.4 Gy TBI and then treated with vehicle or IL-18BP at 48 h post TBI. Mice were sacrificed at day (d) 3, d4 and d7 after TBI. Un-irradiated mice were included for comparison. Sternum bone marrow specimens were stained with IL-18 (a), IFN-γ (b) or rabbit IgG (c) antibodies. Brown color indicates positive staining. Scale bar = 100 µm. Quantification of IL-18 and IFN-γ IHC staining was shown in (d), N = 3.*p < 0.05. Note that the d3 vehicle treated group was significantly different with any other group in the IFN-γ staining.
