Figure 7
From: IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice
Treatment with IL-18BP inhibited ROS levels in irradiated mouse heart tissue. Mice received single dose of rhIL-18BP (2 mg/kg) or vehicle-control SC injection 48 h post- 9.4 Gy TBI and heart tissues were collected on day 3, 4, 7 and 14 after TBI. (a) Representative fluorescent microscopy images of fresh frozen section of mouse heart labeled with DHE. (b) DHE fluorescence intensity was quantified as the ROS levels. 40 cardiomyocytes were randomly selected from 6–8 images in each group (N = 6 mice/group). Means ± SD. Level of increase **p < 0.01; rhIL-18BP-treated vs. vehicle-treated.
