Table 2 All the metabolites affected significantly by the short-term training trial (p-value < 0.05) or fold change > 1.2 or < 0.8.

From: Metabolomics profiling of plasma, urine and saliva after short term training in young professional football players in Saudi Arabia

Mode	m/z	RT (min)	Putative metabolite	Urine		Plasma		Saliva
Mode	m/z	RT (min)	Putative metabolite	Ratio	p-value	Ratio	p-value	Ratio	p-value
			Purine metabolism
+	136.061	8.7	Adenine			1.457	0.182	1.334	0.002
+	137.046	9.7	Hypoxanthine^a	3.453	< 0.001	1.735	0.002	1.796	0.003
−	151.026	11.8	Xanthine			2.027	< 0.001
−	167.021	13.3	Urate			0.766	0.009
+	252.108	7.7	Deoxyadenosine					1.406	0.002
+	253.093	8.3	Deoxyinosine					1.713	0.037
−	283.069	13.0	Xanthosine^a					0.136	0.001
+	298.096	6.4	5-Methylthioadenosine^a			2.395	< 0.001
			Arginine and proline metabolism
−	104.071	13.9	4-Aminobutanoate^a	1.394	0.004			0.661	0.019
−	112.052	9.4	Creatinine			1.278	< 0.001
−	130.051	9.3	l-Glutamate 5-semialdehyde	0.776	0.020
+	131.118	21.2	N-Acetylputrescine					1.313	0.017
+	133.097	23.5	Ornithine^a			1.318	0.001	1.353	0.053
+	146.092	14.9	4-Guanidinobutanoate			1.603	0.014	0.585	0.017
+	148.060	15.1	Glutamate^a			2.014	< 0.001
+	173.104	26.1	Arginine^a			1.521	0.009	1.577	0.013
−	176.103	15.9	l-Citrulline^a			1.456	< 0.001
−	188.057	9.0	N-Acetyl-l-glutamate			1.748	< 0.001
+	217.129	14.6	N-acetylarginine			1.929	< 0.001
+	247.140	13.9	N-(Carboxyethyl) arginine			3.494	< 0.001
			Pyrimidine metabolism
+	112.051	8.8	Cytosine			1.234	0.002	1.793	0.003
+	127.050	13.2	Thymine			1.365	0.004	1.824	0.023
+	129.066	14.6	5,6-Dihydrothymine	1.511	0.006
+	243.097	12.4	Thymidine					2.287	0.002
			Carnitine metabolism
+	204.123	10.4	Acetylcarnitine^a			2.411	< 0.001
+	218.138	9.1	Propionylcarnitine	0.652	0.046
+	244.154	7.6	Tiglylcarnitine			1.549	0.012
+	248.149	10.8	Hydroxybutyrylcarnitine			2.399	< 0.001
	274.201	6.3	Heptanoylcarnitine			1.884	0.036
+	276.144	12.8	Glutarylcarnitine			1.812	< 0.001
+	290.159	12.2	Methylglutarylcarnitine			1.578	0.004
+	302.232	5.1	Dimethylheptanoylcarnitine			1.929	0.054
+	312.217	5.1	Decadienoylcarnitine			1.855	0.013
+	330.227	5.1	Keto-decanoylcarnitine			1.536	0.031
+	330.263	4.7	Dimethylnonanoylcarnitine					1.298	0.002
+	384.270	4.8	Hydroxytetradecadiencarnitine			1.411	0.041
+	386.290	4.7	Hydroxytetradecenoylcarnitine			1.505	0.045
			T.C.A. cycle
−	133.014	16.9	Malate^a			3.226	< 0.001
−	145.014	15.9	2-Oxoglutarate^a			1.954	< 0.001
−	173.009	19.0	cis-Aconitate^a			3.632	< 0.001
−	191.020	19.2	Citrate^a			2.010	< 0.001
			Pentose phosphate pathway
−	133.051	9.3	Deoxyribose			1.330	0.008
−	149.046	11.9	Ribose^a			1.545	< 0.001
−	151.061	12.9	Xylitol or isomer^a			1.328	0.008
−	193.036	16.8	Glucuronate or isomer^a			1.896	< 0.001
−	195.051	15.0	Gluconic acid^a			2.852	0.002
−	229.011	15.7	Ribose 5-phosphate^a					0.145	0.05
			Glycine, serine and threonine metabolism
+	76.076	10.5	Aminopropan-2-ol			2.002	0.018
−	105.019	12.6	Glycerate			1.665	0.001
+	118.061	15.8	Guanidinoacetate	1.604	0.028
+	120.065	11.3	Threonine^a			1.586	0.015
			Lysine metabolism
−	126.056	7.2	2,3,4,5-Tetrahydropyridine-2-carboxylate	1.154	0.021	1.614	0.001
+	146.081	14.6	Hexanoic acid			1.364	0.048	0.232	0.024
+	146.117	12.9	Trimethylammoniobutanoate			1.237	0.001
+	147.113	23.6	l-Lysine^a			1.611	0.02
+	160.097	6.9	Acetamidopentanoate	1.151	0.028
+	162.112	13.3	l-Carnitine^a			3.264	0.011
+	189.159	22.1	N6,N6,N6-Trimethyl-l-lysine			1.859	< 0.001
+	204.086	14.2	N2-Acetyl-l-aminoadipate			1.532	< 0.001
+	205.118	10.3	N6-Acetyl-N6-hydroxy-l-lysine			2.175	< 0.001
+	219.133	14.4	Carboxyethyllysine					1.465	0.017
			Histidine metabolism
+	137.036	7.6	Urocanate^a			1.733	< 0.001
+	141.066	9.7	Methylimidazoleacetic acid			1.632	0.010
+	170.092	12.8	Methylhistidine					0.629	0.029
			Tryptophan metabolism
+	118.065	10.1	Indole^a			1.506	0.028	1.596	0.003
+	161.107	10.1	Tryptamine					1.912	0.003
+	177.102	13.4	Serotonin					1.362	0.056
−	204.067	8.1	Indolelactate			1.394	< 0.001	1.352	0.058
−	219.077	8.9	5-Hydroxy-l-tryptophan isomer					2.043	< 0.001
			Tyrosine metabolism
+	138.091	5.7	Tyramine^a					1.212	0.006
−	179.035	8.3	Hydroxyphenylpyruvate			1.606	< 0.001
−	181.051	9.5	Hydroxyphenyllactate			1.782	< 0.001
+	182.081	12.3	l-Tyrosine^a	0.802	0.056			1.333	0.055
			Valine, leucine and isoleucine degradation
−	115.04	4.8	3-Methyl-2-oxobutanoic acid			0.752	0.002
−	129.056	4.3	Methyl-oxopentanoic acid			0.761	< 0.001
+	132.101	10.8	l-Leucine					1.669	< 0.001
			Phenylalanine metabolism
+	122.096	4.7	Phenethylamine					1.322	0.004
+	123.044	13.3	Benzoate					1.396	0.047
+	136.075	13.3	Phenylacetamide					1.387	0.021
+	149.059	10.1	Cinnamate					1.585	0.003
−	166.086	10.1	Phenylalanine^a					1.606	0.004
			Methionine metabolism
+	150.058	11.3	l-Methionine^a	1.404	0.053
+	166.053	13.4	Methionine S-oxide			1.628	< 0.001
−	176.039	7.2	N-Formyl-l-methionine			1.241	0.004
+	192.105	4.9	Trihomomethionine			1.408	0.010
			Alanine and aspartate metabolism
−	88.04	14.6	l-Alanine^a			1.439	0.002
−	225.099	11.7	Carnosine^a					2.051	0.007
			Fatty acids and metabolites^C4
−	131.071	2.0	Hydroxyhexanoic acid^a,b			1.526	< 0.001
−	227.202	15.9	Tetradecanoic acid^b			1.498	0.015
−	241.218	17.4	Pentadecanoic acid^a,b			1.208	0.035
−	253.218	16.8	Hexadecenoic acid^b			1.374	0.047
−	255.233	18.8	Hexadecanoic acid isomer^b			1.233	0.054
−	281.249	19.5	Octadecenoic acid^b			1.366	0.032
			Miscellaneous
−	147.03	15.8	(R)-2-Hydroxyglutarate			0.674	0.006
+	241.031	16.5	L-Cystine^a	1.041	0.041
−	259.022	15.8	D-Glucose 1-phosphate^a			1.304	< 0.001
+	345.139	12.3	Melibiitol			0.337	0.003
−	448.307	5.2	Glycodeoxycholate			0.196	< 0.001
−	464.302	5.5	Glycocholate^a			1.278	< 0.001

^aMatches retention time of standard.
^bData from runs on ACE C4 column, otherwise run on the pHILIC column.

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Table 2 All the metabolites affected significantly by the short-term training trial (p-value < 0.05) or fold change > 1.2 or < 0.8.

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