Table 3 List of significant gene ontology terms associated with biological processes, molecular functions, and cellular components related to fertility identified by NetworkAnalyst using the protein–protein interaction network built by the prioritized candidate genes for scrotal circumference and sperm motility and the directly connected nodes.

From: Genome-wide association study to identify genomic regions and positional candidate genes associated with male fertility in beef cattle

GO category

GO term

FDRa-corrected p value

Gene names

Biological process

Regulation of MAPK cascade

8.13 × 10–1

TCP1*, PIK3R1

Spermatid differentiation

1

PRLR*

Regulation of hormone secretion

1

ACACA

Acetyltransferase activity

8.88 × 10–4

CDC27, JAK1, GRB2, PIK3R1

Zinc ion binding

2.12 × 10–3

JAK1, PIK3CA, PLK1, CDK1, PI4KA, SGK1, PRKACA

Molecular function

Lipase activity

2.55 × 10–3

GRB2, MAP2K1, PLK1, MAP3K1*, PRKACA, FBXO5*

Endonuclease activity

2.55 × 10–3

PIK3CA, PLK1, CDK1, MAP3K1*, SGK1, PRKACA

Nuclease activity

4.58 × 10–3

JAK1, MAP2K1, PLK1, CDK1, MAP3K1*, SGK1, PRKACA

Cation channel activity

9.51 × 10–3

PLCZ1, PLCB1, PLCB4*

Kinesin complex

1.53 × 10–2

CDC27, PLK1, CDK1

Cellular component

Spindle microtubule

1.53 × 10–2

RAC1, PIK3CA, GRB2, TRAF6, GNA14, MAP2K1, IRAK1, TLR4, TIRAP*, PI4KA, HSP90AA1, XRN1, SGK1, PRKACA, PRLR*, CD40, NPSR1, PPP2CA, RGS17*

Cytosol

4.42 × 10–2

JAK1, JAK3, TUBB4A, PLK1, CDK1, PPP2CA

  1. aFalse discovery rate.
  2. *Prioritized candidate gene identified by GUILDify and ToppGene analysis.
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