Figure 4 | Scientific Reports

Figure 4

From: Efficacy and safety of direct oral anticoagulants for secondary prevention of cancer associated thrombosis: a meta-analysis of randomized controlled trials

Figure 4

Safety (bleeding risk) of DOAC. (a) Major bleeding (MB), (b) clinically relevant non major bleeding (CRNMB), (c) all bleeding (composite MB and CRNMB). Forest plots show risk ratio (RR) of VTE recurrence of pooled data from all studies and subgroup analyses of studies evaluating DOAC compared to LMWH and DOAC compared to VKA. Boxes superimposing RR estimates are proportional to the weight of the included study. Heterogeneity between RCT is assessed by the I2 statistic.

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