Figure 3
Rhythm dissociation in mutant hearts following concomitant deletion of SAN-VGCCs. (A) Line plots of atrial (green line) and ventricular (blue line) rates (left panel) and sample ECGs (right panel) recorded ex vivo on isolated Langendorff perfused heart under control conditions in n = 8 WT, n = 6 Cav3.1−/−, n = 8 Cav1.3−/− and n = 7 Cav1.3−/−/Cav3.1−/−. (B) P wave rates in isolated wild-type and mutant hearts under control conditions. (C) Differences between atrial and ventricular rates of isolated hearts. Statistics: one-way ANOVA followed by Tukey’s multiple comparisons. Whiskers indicate mean ± the SEM. (#) Indicates comparison with wild-type.
