Figure 4 | Scientific Reports

Figure 4

From: Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity

Figure 4

SAN automaticity and distribution of pacemaker leading sites in SAN/atria from wild-type and mutant mice. (A) Sample snapshots of SAN/atria preparations with points showing the position of the pacemaking leading region. Connecting lines indicate alternating leading regions in in the same mutant SAN. (B) Comparison between atrial rates of n = 8 wild-type, n = 8 Cav3.1−/−, n = 7 Cav1.3−/− and n = 6 Cav1.3−/−/Cav3.1−/− SAN/atria preparations. (C) Coefficient of variability of atrial rates from the same mice as in (B). Statistics: one-way ANOVA followed by Tukey’s multiple comparisons test. Whiskers indicate mean ± the SD. (D) Linear regression between the rate from the leading region and the distance from the normal leading region recorded in wild-type preparations. (#) Indicates comparison with wild-type.

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