Figure 2 | Scientific Reports

Figure 2

From: Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5

Figure 2

Preservation of podocyte number in unaffected glomeruli in the mutant mice until 14 W. Immunostaining with p57 with PAS staining in WT and mutant mice, shown are glomeruli without any injury (A). Note clear immunostaining of p57-positive cells limited to the podocyte. Average number of p57-positive cells per glomerular profiles showed no significant difference between WT mice and mutant mice in 6 and 14 week of age (B). Global glomerular sclerosis (C) was parallel with glomerular enlargement (D). Scale bar 20 μm in A.

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