Figure 3 | Scientific Reports

Figure 3

From: Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5

Figure 3

Diffuse podocyte effacement was associated with deep cell infolding into thickened GBM. TEM revealed extreme thickening of GBM and diffuse foot process effacement in podocytes in 30 W mutant mice (A). Severe foot process effacement with actin derangement in podocyte and cellular processes occasionally infolding into GBM in 24 W mutant mice (B, C). Yellow parts in (C) represents GBM. (B) is a larger magnification of the yellow square in (B). Scale bar, 5 μm (A–C).

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