Figure 1
From: Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice
Female TDP-43Q331K/Q331K mice show marked weight gain over time, and age-dependent trends towards increased food intake and reduced marble burying. (a) Body weight from 8 to 21 months of age (n = 6–10 wild-type, 8–10 mutants) is significantly increased in mutants (overall P = 0.0005; mixed-effect analysis). (b) Food intake at 9, 13 and 20 months of age (n = 10 per genotype (9 months); 9 wild-type, 8 mutants (13 months); 8 wild-type, 9 mutants (20 months)) (overall P = 0.3260; two-way ANOVA). (c) Marble burying from 8 to 20 months of age (n = 10 per genotype (8, 9, 10 and 12 months); 9 per genotype (14 months); 8 per genotype (20 months)) shows no significant difference between groups (P = 0.6689; unpaired t-test). Error bars represent mean ± s.e.m, except in (c) where they are median ± interquartile range. ***P < 0.001.
