Table 1 Summary of differences between male and female TDP-43Q331K mice in age of onset of behavioural phenotypes, compared to wild-type.

From: Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice

Phenotype (compared to wild-type)

Age of onset (months)

Male23

Female

Weight gain

8

13

Increased food intake

9a

20b

Reduced marble burying

5

14b

Gait defects

6

20

Reduced running

n/ac

8

Muscle denervation

None

None

  1. aEarliest age at which food intake was measured.
  2. bStatistical trend.
  3. cAs male mice on the C57BL/6 background have low baseline levels for this task69.
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