Figure 2

Association of the microbial distance with renal function at 6 months post-transplantation. (A) Linear regression analysis of the correlation between the estimated glomerular filtration rate (eGFR) at 6 months post-transplantation and weighted UniFrac distance of the microbiome. Solid line, regression line; shaded areas, 95% confidence interval. (B) Receiver operating characteristic curves for allograft dysfunction. The colored area represents 95% confidence interval of ROC curves. Blue line, microbial distance; orange line, number of HLA mismatches; red line, HLA incompatibility; green line, rejection in 6 months. (C) Receiver operating characteristic curves for allograft dysfunction according to clinical variables with (red) and without (blue) microbial distance. The colored area represents 95% confidence interval of ROC curves. Red line, microbial distance with clinical variables including recipient’s age, sex, body mass index, hypertension, diabetes, HLA/ABO compatibility, HLA mismatches and donor-recipient relationship; blue line, clinical variables including recipient’s age, sex, body mass index, hypertension, diabetes, HLA/ABO compatibility, HLA mismatches and donor-recipient relationship.