Figure 2 | Scientific Reports

Figure 2

From: Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia

Figure 2

Sickle cell anemia is linked to a distinct profile of oxidative stress. (A) An unsupervised, two-way hierarchical cluster analysis (Ward’s method with 100 × bootstrap) was employed to depict the overall expression of plasma markers associated with oxidative stress in study population. Two major clusters of markers were observed and are highlighted in red and green boxes on the right. (B) Average fold-difference values in plasma markers for subgroups of SCA participants based on use of hydroxyurea therapy and healthy controls. Differences that reached statistical significance (Mann–Whitney U test) after adjustment for multiple comparisons (adjusted P-value < 0.05) are represented in color bars. Red bars indicate higher values whereas blue bars denote lower values in the comparison group as indicated. (Order of appearance) HO-1 Heme oxygenase-1, HU hydroxyurea, LDH Lactate dehydrogenase, sCD14 Soluble CD14, GSH Glutathione, MDA Malondialdehyde, VEGF Vascular endothelial growth factor, SOD Superoxide Dismutase.

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