Figure 4 | Scientific Reports

Figure 4

From: Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia

Figure 4

Hydroxyurea therapy is associated with coordinated changes in relationships between oxidative stress markers in SCA. Network analysis of the biomarker correlation matrices was performed with bootstrap (100 ×). The graphs show significant correlations (P < 0.05), and the Spearman rank (rho) threshold was ± 0.5. Each node represents a different parameter. The size of each circle (node) is proportional to the number of significant correlations involving such node. Connecting lines represent the Spearman rank coefficient (rho) values. Red color infers positive correlation, whereas blue color denotes negative correlations. Color maps on the right of each network denote the number of significant correlations per parameter (node) per clinical group as indicated. Heatmaps on the right panels rank the markares in each network based on number of statistically significant correlations involving each individual marker. HO-1 Heme oxygenase-1, HU hydroxyurea, LDH Lactate dehydrogenase, sCD14 Soluble CD14, GSH Glutathione, MDA Malondialdehyde, VEGF Vascular endothelial growth factor, SOD Superoxide Dismutase.

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