Figure 4

RNA velocity estimates for each cell type over time. Estimates (arrows) are plotted on a Uniform Manifold Approximation and Projection (UMAP) dimensionality reduction. The length of the arrows represents the transcription rate (velocity) and the direction of the arrows points to the inferred future state of the cell based on other cells present on the UMAP plot. Transparent points are those cells that were filtered out as described in “Results” (cell types in the bone marrow microenvironment). ST-HSC & MLP = short term repopulating cells and multilineage progenitors, GMP = granulocyte–macrophage progenitors, MDP = monocyte-dendritic precursors.