Figure 4

PA (Photoacoustic) images for a tumor-bearing and 800RS-PMPC-administered (2.0 µmol/kg = 40 nmol/20-g mouse) mouse under ambient high-sensitivity conditions with a sensitivity scale of 0–1600 (a), for a tumor-bearing and 800RS-PMPC-administered mouse as in (a) but under hemoglobin-suppressing, low-sensitivity, or high-threshold conditions with a sensitivity scale of 1200–1600 (b), and for a tumor-bearing mouse without administration of 800RS-PMPC under hemoglobin-suppressing, low-sensitivity, or high-threshold conditions (c) as in (b). The PA image in (b) is merged with a bright-field image. (d) shows a schematic representation of coordinate axes illustrating the arrangement of the object (tumor-bearing mouse) and the direction of the incident laser pulse.