Table 3 Crude and adjusted odd ratios (95% confidence interval) of smoking, alcohol consumption, and obesity for thyroid cancer in each stratified group according age and sex.
Characteristics | N of thyroid cancer | N of tontrol | ORs of thyroid cancer | |||
|---|---|---|---|---|---|---|
(Exposure/total, %) | (Exposure/total, %) | Crude† | P-value | Adjusted†‡ | P-value | |
< 55 years (n = 11,640) | ||||||
Smoking status | 164/2328 (7.0%) | 871/9312 (9.4%) | 0.68 (0.59–0.82) | < 0.001* | 0.71 (0.58–0.86) | < 0.001* |
Alcohol consumption | 321/2328 (13.8%) | 1547/9312 (16.6%) | 0.77 (0.67–0.89) | < 0.001* | 0.80 (0.69–0.92) | 0.002* |
Obesity (BMI, kg/m2) | 0.145 | 0.133 | ||||
< 18.5 (underweight) | 32/2328 (1.4%) | 174/9312 (1.9%) | 0.77 (0.52–1.13) | 0.182 | 0.79 (0.54–1.16) | 0.235 |
≥ 18.5 to < 23 (normal) | 895/2328 (38.5%) | 3749/9312 (40.3%) | 1.00 | 1.00 | ||
≥ 23 to < 25 (overweight) | 660/2328 (28.4%) | 2574/9312 (27.6%) | 1.08 (0.96–1.21) | 0.199 | 1.08 (0.96–1.21) | 0.186 |
≥ 25 to < 30 (obese I) | 668/2328 (28.7%) | 2565/9312 (27.6%) | 1.10 (0.98–1.23) | 0.116 | 1.09 (0.97–1.22) | 0.136 |
≥ 30 (obese II) | 73/2328 (3.1%) | 250/9312 (2.7%) | 1.23 (0.94–1.61) | 0.138 | 1.21 (0.92–1.59) | 0.175 |
≥ 55 year (n = 13,245) | ||||||
Smoking | 109/2649 (4.1%) | 747/10,596 (7.1%) | 0.52 (0.42–0.64) | < 0.001* | 0.53 (0.42–0.66) | < 0.001* |
Alcohol consumption | 268/2649 (10.1%) | 1244/10,596 (11.7%) | 0.82 (0.70–0.95) | 0.009* | 0.86 (0.74–1.00) | 0.056 |
Obesity (BMI, kg/m2) | 0.005* | 0.006* | ||||
< 18.5 (underweight) | 29/2649 (1.1%) | 176/10,596 (1.7%) | 0.72 (0.48–1.07) | 0.107 | 0.72 (0.48–1.08) | 0.109 |
≥ 18.5 to < 23 (normal) | 767/2649 (29.0%) | 3348/10,596 (31.6%) | 1.00 | 1.00 | ||
≥ 23 to < 25 (overweight) | 760/2649 (28.7%) | 3034/10,596 (28.6%) | 1.10 (0.98–1.22) | 0.114 | 1.09 (0.97–1.22) | 0.141 |
≥ 25 to < 30 (obese I) | 975/2649 (36.8%) | 3631/10,596 (34.3%) | 1.17 (1.06–1.31) | 0.003* | 1.16 (1.05–1.29) | 0.005* |
≥ 30 (obese II) | 118/2649 (4.5%) | 407/10,596 (3.8%) | 1.27 (1.02–1.58) | 0.035* | 1.25 (1.01–1.56) | 0.045* |
Men (n = 5150) | ||||||
Smoking | 232/1030 (22.5%) | 1291/4120 (31.3%) | 0.63 (0.54–0.74) | < 0.001* | 0.65 (0.55–0.76) | < 0.001* |
Alcohol consumption | 385/1030 (37.4%) | 1744/4120 (42.3%) | 0.82 (0.71–0.94) | 0.004* | 0.85 (0.73–0.98) | 0.024* |
Obesity (BMI, kg/m2) | < 0.001* | < 0.001* | ||||
< 18.5 (underweight) | 8/1030 (0.8%) | 59/4120 (1.4%) | 0.69 (0.32–1.46) | 0.330 | 0.67 (0.31–1.44) | 0.302 |
≥ 18.5 to < 23 (normal) | 232/1030 (22.5%) | 1188/4120 (28.8%) | 1.00 | 1.00 | ||
≥ 23 to < 25 (overweight) | 323/1030 (31.4%) | 1264/4120 (30.7%) | 1.32 (1.09–1.59) | 0.004* | 1.31 (1.08–1.58) | 0.006* |
≥ 25 to < 30 (obese I) | 429/1030 (41.7%) | 1,513/4,120 (36.7%) | 1.46 (1.22–1.74) | < 0.001* | 1.44 (1.20–1.72) | < 0.001* |
≥ 30 (obese II) | 38/1,030 (3.7%) | 96/4,120 (2.3%) | 2.05 (1.37–3.06) | < 0.001* | 2.01 (1.34–3.03) | < 0.001* |
Women (n = 19,735) | ||||||
Smoking | 41/3947 (1.0%) | 327/15,788 (2.1%) | 0.50 (0.36–0.69) | < 0.001* | 0.53 (0.38–0.74) | < 0.001* |
Alcohol consumption | 204/3947 (5.2%) | 1047/15,788 (6.6%) | 0.77 (0.66–0.89) | < 0.001* | 0.80 (0.69–0.94) | 0.006* |
Obesity (BMI, kg/m2) | 0.088 | 0.113 | ||||
< 18.5 (underweight) | 53/3947 (1.3%) | 291/15,788 (1.8%) | 0.75 (0.56–1.02) | 0.062 | 0.76 (0.57–1.03) | 0.077 |
≥ 18.5 to < 23 (normal) | 1430/3947 (36.2%) | 5909/15,788 (37.4%) | 1.00 | 1.00 | ||
≥ 23 to < 25 (overweight) | 1097/3947 (27.8%) | 4344/15,788 (27.5%) | 1.05 (0.96–1.14) | 0.328 | 1.05 (0.96–1.14) | 0.329 |
≥ 25 to < 30 (obese I) | 1214/3947 (30.8%) | 4683/15,788 (29.7%) | 1.07 (0.99–1.17) | 0.107 | 1.07 (0.98–1.17) | 0.116 |
≥ 30 (obese II) | 153/3947 (3.9%) | 561/15,788 (3.6%) | 1.13 (0.94–1.37) | 0.202 | 1.12 (0.93–1.36) | 0.225 |
