Table 3 Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of liposomes with besifloxacin against S. epidermidis and P. aeruginosa planktonic cells.
From: Besifloxacin liposomes with positively charged additives for an improved topical ocular delivery
Treatments | S. epidermidis | P. aeruginosa | ||
|---|---|---|---|---|
MIC (μg/mL) | MBC (μg/mL) | MIC (μg/mL) | MBC (μg/mL) | |
Besifloxacin | 0.156 ± 0.0 | 0.156 ± 0.0 | 0.625 ± 0.0 | 0.625 ± 0.0 |
LP PC | 0.156 ± 0.0 | 0.156 ± 0.0 | 0.625 ± 0.0 | 0.625 ± 0.0 |
LP PC:SPM | 0.156 ± 0.0 | 0.156 ± 0.0 | 0.625 ± 0.0 | 0.625 ± 0.0 |
Besivance | 0.156 ± 0.0 | 0.156 ± 0.0 | 1.25 ± 0.0 | 1.25 ± 0.0 |
LP PC vehicle control | All viable | All viable | All viable | All viable |
LP PC:SPM vehicle control | All viable | All viable | All viable | All viable |
pH 11 HEPES solution | All viable | All viable | All viable | All viable |
Viability control | All viable | All viable | All viable | All viable |
Sterility control | Inviable | Inviable | Inviable | Inviable |
