Figure 13
From: Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells
The co-treatment with coffee decoction and tamoxifen markedly induces apoptosis by activating p53 in MCF-7 cells. A major ingredient of coffee, caffeine reduces the expression of ERα mRNA, which is excessively expressed in breast cancer cells. Caffeine and some ingredients cooperatively inhibit the activation of the MEK-ERK pathway and Akt, which are critical for the proliferation of breast cancer cells. The co-treatment with coffee and tamoxifen cooperatively induce apoptosis by strongly activating p53 in MCF-7 cells.
