Figure 1

Experimental set-up. Pregnant C57Bl/6J mice were injected with 25 µg kg−1 LPS to induce inflammation at gestational day 10.5. An sFlt-1 adenovirus injection at GD 8.5 failed and is therefore not mentioned in the scheme. Half of the offspring received a western-style diet from 12 to 24 weeks of age. Offspring characteristics were analysed at 12 and 24 weeks of age.