Figure 1
From: Alterations in detrusor contractility in rat model of bladder cancer
Macroscopic appearance of the rat bladder in rat model of BBN-induced bladder cancer. (a) Representative images of incised and everted bladders of the rats exposed to BBN in drinking water for 16 weeks, showing the heterogeneity of bladder cancer lesions. (b) For comparison normal intact (left) and incised (right) rat bladder is presented. (c) Examples of detrusor smooth muscle (DSM) strips obtained from the bladders of rats with BBN-induced bladder cancer used for contraction measurements; note papillary-type outgrowths. (d) Histopathological evaluation of lesions identified by H&E stain in rat BBN-induced bladder cancer, from top to bottom: normal urothelium (control), papillary carcinomas showing various degree of dysplasia (cancer 1–3) and simple hyperplasia; right images represent magnified views of boxed parts on the left; calibration bars are in micrometers.
