Figure 3
From: Alterations in detrusor contractility in rat model of bladder cancer
Bladder cancer down-regulates DSM contractions evoked by electric field stimulation (EFS) mostly at the expense of m-cholinergic component. (a) Representative original recordings of EFS-contractions of control-DSM in response to EFS of increasing duration (from left to right 0.4, 1.6, 3.2, 4, 6, 8, 9 and 10 s) before (left) and after exposure to m-cholinergic inhibitor atropine (ATR, 1 µM, right). (b) Quantification (mean ± SD) of the dependence of EFS-contraction amplitude (AEFS) in control DSM on EFS duration in the absence (filled symbols, n = 10) and in the presence of ATR (1 µM, open symbols, n = 10). (c,d) Same as in (a,b), respectively, but for cancer-DSM (mean ± SD, n = 10); note, the decrease of both overall AEFS and the size of ATR-blockable component in cancer- vs. control-DSM; for (b,d) “*” significant difference (P < 0.05) between data points.
