Figure 6
From: Alterations in detrusor contractility in rat model of bladder cancer
Bladder cancer eliminates BK channel-dependent modulation of spontaneous contractions frequency. (a,b) Representative recordings of contractions of DSM strips from normal (control, a) and cancerous (b) bladder in response to application of BK-channel blocker TEA (3 mM); note, strong increase of spontaneous contractions frequency in response to TEA in control DSM (a) and lack thereof in cancer one (b). (c–e) Quantification of the changes in TEA-induced tension (c), amplitude (ASC, d) and frequency (fSC, e) of spontaneous contractions in control (Ctrl, light grey bars, mean ± SD, n = 10) and cancerous (Cncr, dark grey bars, mean ± SD, n = 8) DSM strips; “*” significant difference (P < 0.05) between corresponding values.
