Figure 5 | Scientific Reports

Figure 5

From: Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome

Figure 5

Mechanisms for the prevention of phase-2 reentry (P2R) under β-AS condition. (A,B) The simulated AP propagation (A) and the membrane potential (Vm) change (B) of several myocytes in the myocardial strand model under the same condition as for Fig. 3Ab but during β-AS. (C–F) The gap junctional current, Ig (C), INa in the post-junctional membrane (JM), INa,post-JM (Da), INa in the lateral membrane, INa,LM (Db), and INa in the pre-JM, INa,pre-JM (Dc), The extracellular cleft potentials, Vj (E), ICaL (Fa), Ito (Fb), IKr (Fc), and IK1 (Fd) during β-AS.

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