Table 1 Effects of changes in Na+ channel density of the lateral membrane on epicardial action potential parameters, the regional Na+ channel current, and conduction velocity.

From: Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome

 

100%gNa,LM

35%gNa,LM

7%gNa,LM

0%gNa,LM

APD90 (ms)

241.8

236.9

268.7

80.9

\({\dot{{\varvec{V}}}}_{\mathbf{m}\mathbf{a}\mathbf{x}}\)(mV/ms)

238.6

96.0

39.0

26.5

RMP (mV)

− 87.7

− 87.7

− 87.7

− 87.8

AAP (mV)

122.6

122.4

116.5

51.2

Peak INa,LM (pA/pF)

329.0

138.5

24.6

0.0

Peak post-INa,JM (pA/pF)

951.7

1064.9

1143.9

1162.4

Peak pre-INa,JM (pA/pF)

1035.0

1166.5

1222.8

1211.8

CV (cm/s)

71.4

53.6

33.3

25.0

  1. Each parameter is determined for the LM segment of the 150th cell in the myocardial strand model comprised of 300 epicardial ventricular myocytes.
  2. %gNa,LM a percent gNa in the lateral membrane (LM) segment of each cell of the strand model; APD90 action potential duration measured at 90% repolarization; \({\dot{V}}_{\text{max}}\), maximum upstroke velocity of action potential; RMP, resting membrane potential; AAP, amplitude of action potential; Peak INa,LM, post-INa,JM , and pre-INa,JM, the respective peak values of INa across the LM, post-JM, and pre-JM segments of the 150th cell in the myocardial strand model; CV, conduction velocity.
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