Table 1 26-gene signature that defines MP HGT1 MPBC in NMIBC cohort (Yes = micropapillary, No = non-micropapillary).

From: Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer

Gene

Description

# Patients

Median (normalized expression)

Log2FC

p value

Yes

No

Yes

No

COL4A4

Collagen, type IV, alpha 4

57

21

0.118

2.027

4.099

 < 0.0001

LCN2

Lipocalin 2

58

23

4.057

43.073

3.408

 < 0.0001

KL

Klotho

57

19

0.193

1.992

3.369

 < 0.0001

ABCA13

ATP-binding cassette, sub-family A (ABC1), member 13

62

23

0.769

6.688

3.121

 < 0.0001

FABP3

Fatty acid binding protein 3

61

21

2.262

14.760

2.706

 < 0.0001

CYP1B1

Cytochrome P450 family 1 subfamily B member 1

64

23

0.028

0.125

2.168

 < 0.0001

ANPEP

Alanyl aminopeptidase

63

23

1.067

2.960

1.472

 < 0.0001

DACH2

Dachshund family transcription factor 2

64

23

0.053

0.004

− 3.585

 < 0.0001

KRTAP5-9

Keratin-associated protein 5-9

64

23

0.355

0.022

− 4.018

 < 0.0001

CAPNS2

Calpain small subunit 2

64

23

0.618

0.021

− 4.887

 < 0.0001

KRTAP5-8

Keratin-associated protein 5-8

64

23

0.420

0.009

− 5.576

 < 0.0001

NPAP1

Nuclear pore associated protein 1

64

23

0.040

0.001

− 5.637

 < 0.0001

GDPD2

Glycerophosphodiester phosphodiesterase domain containing 2

64

23

0.212

0.004

− 5.689

 < 0.0001

HECTD2-AS1

HECTD2 antisense RNA 1

64

23

0.091

0.000

− 9.827

 < 0.0001

SNHG8

Small nucleolar RNA host gene 8

64

23

0.114

0.000

− 10.148

 < 0.0001

GABBR2

Gamma-aminobutyric acid (GABA) B receptor, 2

57

23

0.484

6.182

3.675

0.0001

C12orf75

Chromosome 12 open reading frame 75

61

21

3.689

20.363

2.465

0.0003

PKP1

Plakophilin 1

64

23

0.364

0.055

− 2.727

0.0006

CEACAM6

Carcinoembryonic antigen-related cell adhesion molecule 6

57

23

2.124

9.993

2.234

0.0009

CRTAC1

Cartilage acidic protein 1

63

18

12.147

0.983

− 3.627

0.0014

CD36

Platelet glycoprotein IV

64

23

0.128

0.683

2.421

0.0032

IGF2

Insulin-like growth factor 2

64

23

3.876

0.483

− 3.004

0.0038

MMP7

Matrix metallopeptidase 7

51

21

1.847

15.275

3.048

0.0085

RAET1E

Retinoic acid early transcript 1E

60

10

4.012

1.036

− 1.954

0.0124

CHST3

Carbohydrate sulfotransferase 3

64

23

0.820

1.530

0.900

0.0394

TNFRSF11B

TNF receptor superfamily member 11b

64

23

0.032

0.084

1.378

0.0662

Back to article page