Table 2 Comparison of complications, treatment, and clinical outcomes.

From: Adverse impact of renin–angiotensin system blockade on the clinical course in hospitalized patients with severe COVID-19: a retrospective cohort study

 

All (n = 130)

ACE-I/ARB (n = 30)

No ACE-I/ARB (n = 100)

P value

Length of hospital stay, days

23.8 ± 16.5

20.3 ± 14.3

24.9 ± 17.1

0.189

Treatment, n (%)

Antibiotics

99 (76.2)

26 (86.7)

73 (73.0)

0.123

Lopinavir/ritonavir

73 (56.2)

20 (66.7)

53 (53.0)

0.186

Darunavir/cobicistat

33 (25.4)

8 (26.7)

25 (25.0)

0.854

Hydroxychloroquine

91 (70.0)

24 (80.0)

67 (67.0)

0.173

Glucocorticoid

48 (36.9)

13 (44.8)

35 (35.0)

0.374

IVIG

13 (10.0)

2 (6.7)

11 (11.0)

0.731

Oxygen therapy

87 (66.9)

21 (70.0)

66 (66.0)

0.683

Invasive MV

25 (19.2)

7 (23.3)

18.0 (18.0)

0.516

ECMO

4 (3.1)

2 (6.7)

2 (2.0)

0.231

CRRT

9 (6.9)

4 (13.3)

5 (5.0)

0.210

ICU admission

38 (29.2)

10 (33.3)

28 (28.0)

0.595

Complications, n (%)

ARDS

34 (26.2)

14 (46.7)

20 (20.0)

0.004

Acute kidney injury

25 (19.2)

11 (36.7)

14 (14.0)

0.006

Shock

54 (41.5)

15 (50.0)

39 (39.0)

0.284

Clinical outcomes, n (%)

0.008

In-hospital death

36 (27.7)

14 (46.7)

22 (22.0)

 

Recovery

94 (72.3)

16 (53.3)

78 (78.0)

 
  1. ARDS, acute respiratory distress syndrome; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; IVIG, intravenous immunoglobulin; MV, mechanical ventilation.