Table 2 Serum biomarkers for predicting AKI pre and post surgery.

From: Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score

 

Anytime

Biomarkers (n)

AUROC

CI

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Pre operative

MK (128)

0.615

0.513–0.718

57.1

67.4

46.2

76.3

sTNFR2 (174)

0.634

0.546–0.723

65.5

62.2

44.4

79.6

H-FABP (183)

0.712

0.637–0.786

62.1

71.2

50.0

80.2

sTNFR1 (174)

0.729

0.654–0.804

76.4

59.7

46.7

84.5

Post operative

MK (128)

0.678

0.585–0.772

66.7

65.1

48.3

80.0

sTNFR2 (147)

0.734

0.648–0.821

67.4

71.3

51.7

82.8

sTNFR1 (147)

0.795

0.724–0.866

73.9

72.3

54.8

85.9

H-FABP (156)

0.829

0.764–0.893

75.0

74.1

56.3

87.0

H-FABP + sTNFR2 (147)

0.866

0.809–0.924

80.4

81.2

66.1

90.1

H-FABP + sTNFR2 + MK (127)

0.870

0.809–0.932

78.0

84.9

71.1

89.0

H-FABP + sTNFR1 (147)

0.881

0.825–0.937

78.3

87.1

73.5

89.8

H-FABP + sTNFR1 + MK (127)

0.885

0.825–0.944

80.5

86.0

73.3

90.2

  1. AUROC, CI, sensitivity, specificity, PPV and NPV for serum biomarkers for predicting AKI pre and post surgery.
  2. n number, AKI acute kidney injury, AUROC area under the receiver operator characteristic, CI confidence interval, MK midkine, NPV negative predictive value, PPV positive predictive value, sTNFR soluble tumour necrosis factor receptor, H-FABP heart-type fatty acid-binding protein.
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