Table 1 Adipogenesis, lipid metabolism and fibrosis in adipose tissue of 2-month-old mice.

From: Galectin-3 gene deletion results in defective adipose tissue maturation and impaired insulin sensitivity and glucose homeostasis

 

SAT

VAT

BAT

WT

Lgals3−/−

WT

Lgals3−/−

WT

Lgals3−/−

Adipogenesis

Cebpb

0.91 ± 0.41

0.31 ± 0.16†

1.80 ± 1.48

1.77 ± 0.99

1.45 ± 0.47

0.91 ± 0.31

Pparg

0.61 ± 0.25

0.42 ± 0.29*

1.31 ± 0.68

0.96 ± 0.39*

1.03 ± 0.24

0.57 ± 0.16*

Cebpa

0.61 ± 0.24

0.27 ± 0.16*

1.04 ± 0.56

0.56 ± 0.17*

0.90 ± 0.13

0.71 ± 0.08

Lipolysis

Pnpla2

0.47 ± 0.31

0.21 ± 0.10

0.81 ± 0.62

0.64 ± 0.39

0.93 ± 0.16

0.72 ± 0.15

Lipogenesis

Srebf1

0.90 ± 0.39

0.49 ± 0.06*

1.07 ± 0.45

1.14 ± 0.32

0.93 ± 0.06

0.59 ± 0.04‡

Acaca

0.68 ± 0.39

0.63 ± 1.19

0.89 ± 0.32

0.54 ± 0.14*

1.03 ± 0.24

0.17 ± 0.04†

Fasn

0.68 ± 0.76

0.81 ± 1.31

1.09 ± 0.50

0.70 ± 0.68

0.93 ± 0.06

0.13 ± 0.04‡

Fabp4

0.54 ± 0.34

0.24 ± 0.09

0.80 ± 0.60

0.56 ± 0.25

1.03 ± 0.33

0.66 ± 0.09

Adipokines

Lep

0.42 ± 0.33

0.10 ± 0.08*

0.56 ± 0.29

0.17 ± 0.12*

0.80 ± 0.21

0.44 ± 0.26

Adipoq

0.73 ± 0.28

0.45 ± 0.19

1.22 ± 0.64

0.81 ± 0.23

1.04 ± 0.40

0.80 ± 0.20

Cfd

0.83 ± 0.46

0.33 ± 0.12*

1.40 ± 1.02

0.87 ± 0.33

1.10 ± 0.37

0.87 ± 0.12

Browning

Cidea

0.34 ± 0.37

0.08 ± 0.02*

0.87 ± 0.86

0.65 ± 0.85

0.95 ± 0.18

0.72 ± 0.19

Ppara

0.50 ± 0.36

0.13 ± 0.06*

1.59 ± 0.99

1.12 ± 0.73

1.17 ± 0.36

0.74 ± 0.25

Ucp1

N/A

N/A

N/A

N/A

0.91 ± 0.17

0.42 ± 0.16*

Insulin signaling

Slc2a4

0.45 ± 0.38

0.06 ± 0.08*

1.35 ± 0.35

0.73 ± 0.22‡

0.97 ± 0.04

0.31 ± 0.08‡

Insr

0.70 ± 0.30

0.47 ± 0.15

1.10 ± 0.34

1.42 ± 0.39

1.04 ± 0.17

0.87 ± 0.04

Irs1

0.84 ± 0.23

0.50 ± 0.24*

1.02 ± 0.60

0.70 ± 0.25

1.46 ± 0.94

1.12 ± 0.24

Fibrosis

Fn1

1.67 ± 1.73

0.64 ± 0.22

2.32 ± 1.72

3.65 ± 1.06

1.14 ± 0.17

0.94 ± 0.06

Cola1a1

3.32 ± 4.22

2.76 ± 2.96

1.44 ± 0.85

3.01 ± 1.75

0.92 ± 0.10

1.36 ± 0.17*

Cola4a1

0.49 ± 0.29

0.25 ± 0.10

0.84 ± 0.56

1.02 ± 0.66

0.97 ± 0.13

1.26 ± 0.01*

Cola6a1

0.58 ± 0.24

0.36 ± 0.12

1.06 ± 0.68

1.51 ± 1.28

0.98 ± 0.03

1.47 ± 0.41

  1. Expression of genes involved in adipogenesis, white and brown/beige lipid metabolism, insulin signaling, and fibrosis in SAT, VAT and BAT from 2-month-old WT and Lgals3−/− mice.
  2. Values represent the mean ± SD (n = 7 per genotype). P values calculated by t-test between WT and Lgals3−/−: *P < 0.05; †P < 0.01 and ‡P < 0.001 versus the corresponding WT mice.
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