Table 2 Adipogenesis, lipid metabolism and fibrosis in adipose tissue of 5-month-old mice.

From: Galectin-3 gene deletion results in defective adipose tissue maturation and impaired insulin sensitivity and glucose homeostasis

 

SAT

VAT

BAT

WT

Lgals3−/−

WT

Lgals3−/−

WT

Lgals3−/−

Adipogenesis

Cebpb

1.31 ± 1.63

0.80 ± 0.58

1.34 ± 1.02

0.78 ± 0.47

0.84 ± 0.22

0.99 ± 0.78

Pparg

0.67 ± 0.50

0.60 ± 0.21

0.75 ± 0.19

0.61 ± 0.20

1.01 ± 0.02

1.16 ± 0.01*

Cebpa

0.80 ± 0.60

0.74 ± 0.31

1.07 ± 0.64

0.93 ± 0.41

1.03 ± 0.04

0.89 ± 0.04*

Lipolysis

Pnpla2

1.12 ± 1.19

0.86 ± 0.58

0.40 ± 0.60

0.31 ± 0.45

1.01 ± 0.01

0.99 ± 0.02

Lipogenesis

Srebf1

0.80 ± 0.55

0.69 ± 0.37

0.87 ± 0.31

0.84 ± 0.23

0.92 ± 0.11

0.70 ± 0.14

Acaca

1.55 ± 2.04

1.39 ± 0.73

0.98 ± 0.53

0.99 ± 0.44

0.79 ± 0.29

0.96 ± 0.44

Fasn

0.65 ± 0.51

0.75 ± 0.38

0.97 ± 0.67

0.84 ± 0.43

0.76 ± 0.34

0.61 ± 0.12

Fabp4

1.11 ± 0.86

1.05 ± 0.40

4.18 ± 3.68

3.16 ± 3.03

0.99 ± 0.01

0.72 ± 0.16

Adipokines

Lep

1.54 ± 2.38

0.58 ± 0.49

1.23 ± 0.76

1.17 ± 0.80

0.67 ± 0.47

1.25 ± 0.78

Adipoq

0.84 ± 0.77

0.66 ± 0.31

0.72 ± 0.19

0.75 ± 0.16

1.02 ± 0.02

1.10 ± 0.08

Cfd

0.79 ± 0.79

0.72 ± 0.39

0.87 ± 0.32

0.83 ± 0.31

1.00 ± 0.005

0.91 ± 0.11

Browning

Cidea

2.91 ± 2.32

1.68 ± 0.75

1.06 ± 1.38

0.13 ± 0.12*

0.92 ± 0.12

0.94 ± 0.07

Ppara

1.26 ± 0.69

0.96 ± 0.35

0.88 ± 0.63

0.46 ± 0.28

0.98 ± 0.03

0.98 ± 0.21

Ucp1

N/A

N/A

N/A

N/A

1.13 ± 0.18

0.70 ± 0.13*

Insulin signaling

Slc2a4

0.89 ± 0.94

0.62 ± 0.35

0.89 ± 0.57

0.64 ± 0.28

0.82 ± 0.25

0.72 ± 0.06

Insr

0.62 ± 0.43

0.56 ± 0.35

0.76 ± 0.37

0.84 ± 0.36

1.09 ± 0.13

0.90 ± 0.09

Irs1

1.00 ± 0.93

0.87 ± 0.51

1.10 ± 0.34

1.07 ± 0.39

1.54 ± 0.76

1.98 ± 0.73

Fibrosis

Fn1

0.45 ± 0.38

0.71 ± 0.33

1.40 ± 0.79

1.86 ± 0.82

1.03 ± 0.04

1.40 ± 0.32

Cola1a1

0.26 ± 0.38

0.19 ± 0.10

1.31 ± 0.78

1.68 ± 0.94

1.11 ± 0.16

1.98 ± 0.11†

Cola4a1

0.62 ± 0.52

0.54 ± 0.25

1.00 ± 0.32

1.23 ± 0.50

0.99 ± 0.01

1.08 ± 0.36

Cola6a1

0.61 ± 2.12

1.46 ± 1.15

1.80 ± 1.71

2.41 ± 2.04

1.18 ± 0.26

1.50 ± 0.49

  1. Expression of genes involved in adipogenesis, white and brown/beige lipid metabolism, insulin signaling, and fibrosis in SAT, VAT and BAT from 5-month-old WT and Lgals3−/− mice.
  2. Values represent the mean ± SD (n = 7 per genotype). P values calculated by t-test between WT and Lgals3−/−: *P < 0.05; †P < 0.01 and ‡P < 0.001 versus the corresponding WT mice.
Back to article page