Table 1 Binding kinetics of TRAIL-ATNC and TRAIL against TRAIL receptor DR5.

From: Designed ferritin nanocages displaying trimeric TRAIL and tumor-targeting peptides confer superior anti-tumor efficacy

Ligand

kon (M−1 S−1)a

koff (S−1)a

KD (M)b

TRAIL-ATNC

(3.77 ± 0.24) × 105

(9.15 ± 9.14) × 10–5

(2.56 ± 2.58) × 10–10

TRAIL

(2.58 ± 0.60) × 104

(1.50 ± 0.38) × 10–3

(6.02 ± 1.99) × 10–8

  1. aObtained by saturated binding responses at least three independent runs of SPR measurements.
  2. bKD = koff/kon.
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