Table 5 Association of steady state plasma imatinib levels with response- comparison with previous studies.

Reference	N	Response	Responder		Non responders		p value
Reference	N	Response	N	Mean C0 ng/mL	N	Mean C0 ng/mL	p value
Larson et al., 2008¹⁶	351	CCyR	297	1099 ± 554	54	812 ± 409	0
Takahashi et al., 2010⁵¹	254	CCyR	218	1057 ± 585	36	835 ± 524	0.033
Takahashi et al., 2010⁵¹	254	MMR	166	1107 ± 594	88	873 ± 528	0.002
Picard et al., 2007¹⁷	68	CCyR	56	1123 ± 617	12	694 ± 556	0.03
Picard et al., 2007¹⁷	68	MMR	34	1452 ± 649	34	869 ± 427	0.001
Ishikawa et al., 2010²⁶	60	MMR	38	1093	22	853	0.002
Ishikawa et al., 2010²⁶	60	MMR		562–2150		361–1205	0.002
Forrest et al., 2009⁵²	78	CCyR	53	1010 ± 469	24	1175 ± 656	0.29
Forrest et al., 2009⁵²	78	MMR	51	1067 ± 473	27	1063 ± 643	0.74
Singh et al., 2009⁵³	40	Clinical response	20	2340 ± 520	20	690 ± 150	0.002
Malhotra et al., 2014⁴³	131	Molecular response (< 1%)	104	2110 ± 1180	27	1310 ± 720	0.001
Natarajan et al. 2019⁵⁴	173	MMR	71	2333 ± 1112	102	1643 ± 1384	P < 0.001
Arora et al., 2013⁴⁴	46	CCyR	NA	2157 ± 1287	NA	1884 ± 809	P > 0.05
Present study	51	EMR@3 months	28	1532 ± 939	23	971 ± 714	0.022*
Present study	65	MMR@12 months	28	1566 ± 991	37	1160 ± 921	0.042*

Quick links

Search