Figure 1 | Scientific Reports

Figure 1

From: Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome

Figure 1

Expression of genes associated with eosinophil recruitment, proinflammatory and secretory activity. Gene expression analysis of (A) chemotactic (B) cationic and (C) survival eosinophil-related genes. Individual values represent the fold change with respect to the average of the HC group. C–C chemokine receptor 3 (CCR3), C–C motif chemokine 11, 24 and 26 (CL11, CCL24 and CCL26, eotaxins 1, 2 and 3, respectively), colony stimulating factor 2 (CSF2); eosinophil major basic protein (MBP, Proteoglycan 2, PRG2), Charcot-Leyden crystal galectin (CLC), eosinophil-derived neurotoxin (ribonuclease A family member 2, RNASE2), eosinophil cationic protein (ribonuclease A family member 3, RNASE3), eosinophil peroxidase (EPX); interleukin-5 (IL-5). P value adjusted (false discovery rate): *P < 0.05, **P < 0.01; ***P < 0.001. HC, healthy control; IBS-D, diarrhea-predominant IBS (HC, n = 7–12; IBS-D, n = 12–17).

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