Figure 6
From: Synaptic activity and strength are reflected by changes in the post-synaptic secretory pathway
Summary of effects and proposed model. (a) Summary of the correlation between the elements of the secretory pathway (in terms of distribution and levels), and post-synaptic strength (homer), pre-synaptic strength (vGLUT1), or pre-synaptic activity (SYT1) for the different analysis performed (automatic analysis of all synapses, or manual analyses of mushroom spines and stubby spines). The different shades of grey correspond to high correlation/influence (darker grey), or less (light grey) to no (white) correlation/influence. (b) Model for the effect of synaptic strength and activity on the elements of the secretory pathway. Increased activity initially mobilizes the locally available resources, whose availability increases to support spine enlargement and maintenance.
