Table 3 Differentially expressed SLC transporters in PVEC vs. ABEC.
Gene | Fold change | Protein name | Substrates | Family |
|---|---|---|---|---|
Slc1a3 | 1465.89 | EAAC1, EAAT1 | L-Glu, D/L-Asp | High-affinity glutamate and neutral amino acid transporter |
Slco1c1 | 654.22 | OATP1C1 | T4, T3, rT3 | Organic anion transporter |
Slc2a3 | 489.48 | GLUT3 | Glucose, galactose, mannose, xylose | Facilitative GLUT transporter |
Slc4a3 | 295.16 | AE3 | Chloride bicarbonate | Bicarbonate transporter |
Slc6a15 | 280.17 | NTT73 | Large, neutral amino acids | Sodium- and chloride-dependent neurotransmitter transporter |
Slc16a9 | 247.31 | MCT9 | Monocarboxylate transporter | |
Slc25a23 | 236.53 | APC2 | ATP-Mg2+, ATP, ADP, AMP, Pi | Mitochondrial carrier |
Slco1a5 | 170.64 | OATP-3 | Taurocholate and thyroid hormones | Organic anion transporter |
Slc39a12 | 140.97 | ZIP12j, LZT-Hs8 | Zn | Metal ion transporter |
Slc16a2 | 131.42 | MCT8 | T2, rT3, T3, T4 | Monocarboxylate transporter |
Slc38a3 | 130.64 | SNAT3 | Q, H, A, N | System A and System N sodium-coupled neutral amino acid transporter |
Slc4a4 | 108.59 | NBCe1 | Sodium bicarbonate (and/or carbonate) | Bicarbonate transporter |
Slc7a2 | 107.45 | CAT-2 (A or B) | Cationic l-amino acids | Cationic amino acid transporter/glycoprotein-associated |
Slc15a2 | 98.45 | PEPT2 | Di- and tri-peptides, protons, beta-lactam antibiotics | Proton oligopeptide cotransporter |
Slc6a1 | 76.36 | GAT-1 | GABA | Sodium- and chloride-dependent neurotransmitter transporter |
Slc6a17 | 73.98 | NTT4 | Neutral amino acids | Sodium- and chloride-dependent neurotransmitter transporter |
Slc2a13 | 73.70 | HMIT | Myo-inositol | Facilitative GLUT transporter |
Slc1a2 | 69.88 | EAAC1, EAAT3 | L-Glu, D/L-Asp | High-affinity glutamate and neutral amino acid transporter |
Slc24a3 | 69.45 | Na+/K+/Ca2+-exchange protein 3 | Na+/(Ca2+-K+) exchange | |
Slc22a18 | 0.0154 | ORCTL-2 | Probably organic anions | Organic cation/anion/zwitterion transporter |
Slc6a3 | 0.0124 | DAT | Dopamine | Sodium- and chloride-dependent neurotransmitter transporter |
Slc16a11 | 0.0106 | MCT11 | Pyruvate | Monocarboxylate transporter |
Slc46a3 | 0.0102 | Lysosomal export of maytansine conjugates | Folate transporter family | |
Slc24a1 | 0.0096 | NCKX1 | Na+, Ca2+, K+ | Na+/(Ca2+-K+) exchange |
Slc9b1 | 0.0015 | NHE1 | Na+, Li+, H+, NH4+ | Na+/H+ exchanger |
