Figure 5 | Scientific Reports

Figure 5

From: The synergistic tumor growth-inhibitory effect of probiotic Lactobacillus on transgenic mouse model of pancreatic cancer treated with gemcitabine

Figure 5

Representative images of pancreatic sections after receiving high-dose (n = 3) or low-dose (n = 3) probiotic treatment alone in caerulein-treated KC transgenic mice (GMNL133:GMNL89 = 1:1/10, 1/3 × vs. GMNL133: GMNL89 = 1:1/10, 10x). The group receiving 10 × higher probiotic doses showed a lower grade of PanIN progression in H&E staining and a lower expression of vimentin and Ki-67 staining. Cae, caerulein; H&E, Hematoxylin and eosin; KC, LSL-KrasG12D/-; PDX-1-Cre transgenic mice; PanIN, pancreatic intraepithelial neoplasia.

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