Table 4 ASD screening accuracy of ROS scavenging activities alone and in combination.

From: Simultaneous evaluation of antioxidative serum profiles facilitates the diagnostic screening of autism spectrum disorder in under-6-year-old children

ROS scavenging activity

Total

6 years old and younger

OR

Sens

Spec

LR+

CC

AUC

OR

Sens

Spec

LR+

CC

AUC

·OH

1.85

0.74

0.40

1.22

0.53

0.61

2.18

0.74

0.44

1.31

0.55

0.65

RO·

1.90

0.53

0.63

1.42

0.59

0.65

8.40

0.74

0.75

2.95

0.75

0.77

O2·−

4.82

0.69

0.68

2.17

0.69

0.76

27.10

0.74

0.91

7.86

0.84

0.87

·OH + RO·

2.51

0.57

0.65

1.65

0.62

0.69

6.64

0.72

0.72

2.57

0.72

0.79

·OH + O2·−

4.82

0.69

0.68

2.17

0.69

0.77

35.00

0.78

0.91

8.56

0.84

0.88

RO·. + O2·−

4.13

0.67

0.67

2.02

0.71

0.79

32.50

0.68

0.94

10.90

0.84

0.94

·OH + RO·. + O2·−

6.92

0.67

0.78

2.97

0.73

0.83

50.40

0.77

0.94

12.60

0.87

0.94

·OH + RO·. + O2·− + 1O2

8.86

0.76

0.74

2.92

0.75

0.85

31.40

0.68

0.94

10.60

0.84

0.95

ROS scavenging activity

Male

Male 6 years old and younger

OR

Sens

Spec

LR+

CC

AUC

OR

Sens

Spec

LR+

CC

AUC

·OH

3.4

0.84

0.40

1.4

0.64

0.70

1.6

0.71

0.39

1.2

0.53

0.65b

RO·

2.3

0.57

0.63

1.6

0.60

0.69

9.4

0.86

0.61

2.2

0.72

0.78

O2·−

9.5

0.60

0.87

4.5

0.72

0.72

20.0

0.71

0.89

6.4

0.81

0.88

·OH + RO·

4.9

0.68

0.70

2.3

0.69

0.77

7.3

0.79

0.67

2.4

0.72

0.82b

·OH + O2·−

6.1

0.65

0.77

2.8

0.72

0.77

20.0

0.71

0.89

6.4

0.82

0.88b

RO·. + O2·−

6.9

0.68

0.77

2.9

0.72

0.79

42.5

0.71

0.94

12.9

0.88

0.94

·OH + RO·. + O2·−

6.3

0.73

0.70

2.4

0.72

0.85

86.3

0.71

1.00

a

0.88

0.94b

·OH + RO·. + O2·− + 1O2

12.4

0.76

0.80

3.8

0.78

0.87

42.5

0.71

0.94

12.9

0.89

0.95b

  1. ROS reactive oxygen species, ASD autism spectrum disorder, ·OH hydroxyl radical, RO· alkoxyl radical, O2·− superoxide, 1O2 singlet oxygen, OR odds ratio, Sens sensitivity, Spec specificity, LR+ positive likelihood ratio, CC percentage of correct classification, AUC area under the receiver operating characteristic curve.
  2. aIncomputable because the specificity is 1.0
  3. bNot significant.
Back to article page