Figure 1 | Scientific Reports

Figure 1

From: α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice

Figure 1

αSyn and IAPP co-localize in mouse and human islet amyloid. (a-f) TEM images of fibrils extracted from 3 independently pooled hIAPPtg mouse pancreases, 2 pooled pancreases/extract, (a-c), and human islets (d-f) (donors #4, 5, and 6 from left to right) showing immuno-gold labelled αSyn (sc-7011R, 15 nm gold particles) and IAPP (NBP1-06579, gold 10 nm gold particles). Black arrows and white circle indicate αSyn and arrow heads indicate IAPP labelled gold particles. Scale bar is 100 nm in (a–f).

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