Figure 5
From: α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice
Reduced amyloid formation in hIAPPtg mice devoid of endogenous αSyn. (a) Representative images of Thio-S+ amyloid deposits in islets from 10 weeks old wild type (wt), Snca−/−, hIAPPtg, and hIAPPtg;Snca−/− mice. (b) Quantification of percentage Thio-S+ amyloid area/islets area from 10 weeks old wt and Snca−/− mice and 10 and 20 weeks old hIAPPtg and hIAPPtg;Snca−/− mice. Please see “Amyloid analyses” in the Materials and methods section for information on numbers of islets and mice analysed for each category. Scale bar is 100 µm. Data are presented as mean + /- SEM, *P < 0.05, ***P < 0.001.
