Table 2 Multiple cox regression models of overall survival in mesothelioma patients.
Variables | Model 1 (including fibulin-3) | Model 2 (including HMGB1) | Model 3 (including combination of fibulin-3 and HMGB1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | Z | P | HR | 95% CI | Z | P | HR | 95% CI | Z | P | |
Gender: female versus male | 1.18 | 0.65–2.15 | 0.54 | 0.59 | 1.11 | 0.61–2.02 | 0.34 | 0.73 | 1.07 | 0.59–1.93 | 0.22 | 0.83 |
Age: ≥ 60 y ears versus < 60 years | 1.69 | 0.98–2.91 | 1.89 | 0.06 | 1.73 | 1.00–2.98 | 1.96 | 0.05 | 1.02 | 1.00–1.04 | 1.88 | 0.06 |
Subtype: non-epithelioid versus epithelioid | 0.70 | 0.28–1.75 | − 0.76 | 0.45 | 0.81 | 0.33–1.99 | − 0.46 | 0.65 | 0.83 | 0.35–1.96 | − 0.42 | 0.67 |
Site: peritoneal versus pleural | 1.08 | 0.63–1.86 | 0.27 | 0.79 | 1.12 | 0.64–1.93 | 0.39 | 0.70 | 0.97 | 0.57–1.67 | -0.09 | 0.93 |
Treatment: non-surgery versus surgery | 0.84 | 0.46–1.53 | − 0.57 | 0.57 | 0.89 | 0.49–1.61 | − 0.38 | 0.70 | 0.84 | 0.46–1.53 | − 0.56 | 0.58 |
Fibulin-3 expression: high versus low | 1.91 | 1.09–3.33 | 2.27 | 0.02 | – | – | – | – | – | – | – | – |
HMGB1 expression: high versus low | – | – | – | – | 1.22 | 0.72–2.05 | 0.73 | 0.47 | – | – | – | – |
Combination of fibulin-3 and HMGB1: positive versus negative | – | – | – | – | – | – | – | – | 1.67 | 0.98–2.85 | 1.87 | 0.06 |
