Figure 2 | Scientific Reports

Figure 2

From: Proteomics analysis of serum small extracellular vesicles for the longitudinal study of a glioblastoma multiforme mouse model

Figure 2

Comparison of PPT and SEC sEV isolation methods. (A) Extracted protein amount from SEC- and PPT-sEV’s. The number of identified protein groups is described in B. Welch’s test: *p < 0.05, **p < 0.01, ***p < 0.001. Data are mean ± SD. (B) Number of identified protein groups of SEC- and PPT-sEV’s. Data are mean ± SD. (C) Venn diagram showing overlap of proteins identified from the SEC and PPT preparations. Dark grey circles indicate PPT IDs, light grey circles indicate SEC IDs. (D) Transmission electron microscopy images at low and high magnification of negative staining sEV’s obtained by PPT and by SEC. (E) Dynamic light scattering analysis and relative dimension distribution obtained for PPT-EV and SEC-EV. Data are mean (nm) ± SD.

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