Figure 2
Amyloid burden estimations in intact heads corresponding to 5XFAD mice and WT controls. (a) Approximate studied locations in the mouse brain in comparison to an anatomic reference image from the Allen Mouse Brain Atlas containing major brain regions in a sagittal plane25. (b) Correlation between the \(\Delta \)AUP calculated from the sSAXS method and the amyloid load estimates derived from histology for three locations (Pearson \(r = 0.94, P < 0.001\)). (c) Corresponding S(q) of AD and WT mice used for \(\Delta \)AUP calculation after studying their heads with an intact skull in each location for 300 s. Error bars represent ± standard deviation from three measurements for each location. (d) Representative histology images of AD and WT brain slices using Thioflavin S. The zoomed image (top) is focused on the hippocampus of AD brain slice.
